Tag: allergy

The PALACE Trial: Direct Oral PCN Challenge in Patients with Low-Risk PCN Allergy?

by Salim Rezaie posted August 3, 2023 No Comments

Background: Many patients report a vague history of penicillin allergy. The vast majority of these self-reported allergies are untrue (< 5%) . Literature including patients with penicillin allergies also show longer, more complicated hospital courses. Standard practice for identifying errant allergy ...

Allergy and Immunology

Cetirizine Vs Diphenhydramine For the Treatment of Acute Urticaria in the ED

by Nadia Adside, MD posted January 23, 2023 No Comments

Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergic reactions. Despite being highly effective in treating acute allergic reactions, first-generation H1 antihistamines cross the blood-brain barrier and bind to H1 receptors, which can ...

Allergy and Immunology