Background: The most severe SARS-CoV-2 infections result in an intense inflammatory response which can lead to acute lung injury and/or acute respiratory distress syndrome. Theoretically, potential treatments for severe disease should have anti-inflammatory action without substantial side effects. One candidate …
Background: As the COVID-19 pandemic continues a number of challenges have arisen. Amongst these is the ability of clinicians to predict which patients will suffer from early decompensation. It is well established that there are patients that will rapidly decline …
Background: Hydroxychloroquine (HCQ) is an antimalarial and immunomodulatory drug that is postulated to exert an antiviral effect by increasing intracellular pH resulting in decreased viral binding at the ACE2 receptor. Azithromycin is a macrolide antibiotic that also has anti-inflammatory and …
Background: We have been in need of a sign of hope in the fight against SARS-CoV-2 as it runs from city to city overwhelming health systems. The majority of patients will be either asymptomatic or have only mild disease. These …
Background: Despite the initial excitement around the use of chloroquine (CQ) and hydroxychloroquine (HCQ), there is mounting evidence that neither drug is effective in COVID-19 treatment. Laboratory studies have shown antiviral and immunomodulatory properties in vitro but these have not …
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