Background: Over the past few years, corticosteroids have gained traction in the treatment of patients with ARDS and septic shock. Trials such as APROCCHSS and ADRENAL have shown that the use of corticosteroids is associated with more rapid resolution of …
Background: The most severe SARS-CoV-2 infections result in an intense inflammatory response which can lead to acute lung injury and/or acute respiratory distress syndrome. Theoretically, potential treatments for severe disease should have anti-inflammatory action without substantial side effects. One candidate …
Background: Patients coming to the ED frequently have several interventions performed in their evaluation and management. Blood draws, for the most part, are venous. Occasionally, however, arterial sampling is used to gauge acid-base status, PaO2, PaCO2, lactate etc. This is …
Background: The scientific process in medicine is complicated. Obtaining high-quality data to guide management requires hypothesis formulation, data to support the hypothesis and study replication. Time and again beneficial findings in therapeutic studies fail to be replicated in subsequent studies. …
Background: The cornerstones of sepsis management continues to include early identification, early appropriate empiric antibiotics, definitive source control, and vasopressors to support end organ perfusion. There have been multiple studies looking at the co-administration of hydrocortisone, ascorbic acid, and thiamine …
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