Tag Archive for: Andexanet Alfa

ANNEXA-4: Andexanet Alfa and Factor Xa Inhibitors

04 Mar
March 4, 2019

Background: Over the past few years we have seen a surge in the use of oral Factor Xa inhibitors (apixaban, rivaroxaban etc) for anticoagulation.  The reason for this is the ease of use, standard dosing with no levels to check and no injections needed. Despite these advantages, the risk of bleeding remains a concern.  These agents unfortunately do not have any specific reversal agents.  In May of 2018, Andexanet alfa gained accelerated approval by the FDA for the reversal of these agents, but robust evidence in its support have been lacking. Read more →