Welcome to the September REBELCast 2014, where Matt, Swami, and I are going to tackle a couple more scenarios to help your clinical practice. Today, we are going to specifically tackle two different topics:
Topic #1: The use of Non-Invasive Positive Pressure Ventilation (NIPPV) in the Pre-Hospital Treatment of Patients with Severe Respiratory Distress
Topic #2: Once Weekly Dalbavancin for Skin Infections
September REBELCast 2014 Podcast
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What are the clinical questions that will be covered in September REBELCast 2014?
Question #1: In patients with undifferentiated respiratory distress, does the use of NIPPV in the pre-hospital setting reduce in-hospital mortality?
Question #2: Is weekly dosing of Dalbavancin as effective as routine therapy for skin infections?
What are the specific articles we will be covering?
Article #1: Mal S et al. Effect of Out-of-Hospital NonInvasive Positive-Pressure Support Ventilation in Adult Patients with Severe Respiratory Distress: A Systematic Review and Meta-Analysis. Ann of EM 2014; 63: 600 – 7. (24342819)
Article#2: Boucher HW et al. Once-Weekly Dalbavancin Versus Daily Conventional Therapy for Skin Infection. N Engl J Med 2014; 370: 2169 – 79. (24897082)
What are the clinical bottom lines for the above clinical questions:
Bottom Line #1: NIPPV should be considered in all patients with severe respiratory distress in the prehospital setting
Bottom Line #2: IV Dalbavancin is an alternative antibiotic for skin infections that can be dosed on a weekly basis, but as with other new medications, cost may be an issue and a non-drug company sponsored study would need to be conducted before implementation.
September REBELCast 2014 Show Notes
For more on the above topics checkout:
- Ryan Radecki at Emergency Medicine Literature of Note: Let’s Make MRSA Stronger
- Zlatan Coralic at Academic Life in EM (ALiEM): New Antibiotic Dalbavancin: Should We Use This in the ED?