Facebook Twitter Google+ Pinterest LinkedIn Reddit PocketDefinition: A dysfunctional condition in which removal of baclofen, an inhibitory neurotransmitter, from the central nervous system (CNS) causes CNS excitation.
Archive for category: Toxicology
Facebook Twitter Google+ Pinterest LinkedIn Reddit PocketBackground: Severe alcohol withdrawal syndrome (AWS) accounts for only 10% of the roughly 500,000 annual cases of AWS episodes that require pharmacologic treatment. AWS is characterized by an imbalance between inhibitory GABA and excitatory NMDA receptor stimulation secondary to chronic ethanol intake. Treatment is typically centered around supportive care and symptom-triggered […]
Facebook Twitter Google+ Pinterest LinkedIn Reddit PocketFrequently, patients with acute alcohol intoxication are brought to the emergency department (ED) for evaluation and treatment. Although practice patterns vary, it is not an uncommon practice to give normal saline to these patients in the hopes that the saline will cause a dilution effect on the level of […]