Archive for category: Pharmacology

REBEL Cast Episode 39 – The TOAST Trial: Dexamethasone for Acute Pharyngitis

24 Jul
July 24, 2017

Background: Sore throat is a common presentation to the emergency department as well as primary care clinics.  Corticosteroids inhibit transcription of pro-inflammatory mediators in airway endothelial cells responsible for pharyngeal inflammation and symptoms of pain.  They have been used in other upper respiratory tract infections such as acute sinusitis and croup.  In adults, previous studies […]

Alternative Headache Therapies

15 Jun
June 15, 2017

Background: Presentations to the Emergency Department for acute headache are remarkably common, with more than 2 million visits each year in the United States (Goldstein 2006). Emergency clinicians are tasked with dual roles of excluding life-threatening pathology while rendering effective pain relief and symptomatic care. Treatment patterns for isolated benign headache are widely variable, reflecting the […]

Is Amiodarone Dead?

12 Jun
June 12, 2017

Background: Amiodarone is a class III antidysrhythmic first released for human use in 1962. As with other drugs in this class, amiodarone acts by blocking potassium channels thus prolonging the action potential. This, in turn, leads to a lengthening of depolarization of the atria and ventricles. The drug spread rapidly through US hospitals as it was […]

What’s Your Drug Shortage Plan: Part II

01 Jun
June 1, 2017

Many drugs critical to patient management are showing up on national shortages (most pertinent to the ED list below).  Is your institution feeling the effects?  Do you have a drug shortage plan? In this post we will cover potential alternatives to combat drug shortages for the following medications: Sodium Bicarbonate Promethazine Rocuronium

What’s Your Drug Shortage Plan: Part I

29 May
May 29, 2017

Many drugs critical to patient management are showing up on national shortages (most pertinent to the ED list below).  Is your institution feeling the effects?  Do you have a drug shortage plan? In this post we will cover potential alternatives to combat drug shortages for the following medications: Atropine Calcium Chloride Calcium Gluconate Dextrose 50% Epinephrine […]

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