Archive for category: Infectious Disease

The Marik Protocol: Have We Found a “Cure” for Severe Sepsis and Septic Shock?

07 Apr
April 7, 2017

Background: The overall mortality in sepsis has decreased quite a bit in the last decade or so, however for a subset of patients, like those with Septic Shock, the mortality still remains high (as high as 50%).  There have been hundreds of studies trying to identify the holy grail to decrease mortality further, but one […]

Episode 35 – Non Operative Treatment of Appendicitis (NOTA)

03 Apr
April 3, 2017

Background: Historically the treatment of uncomplicated appendicitis has been appendectomy. The first appendectomy performed dates back to 1735 done by Claudius Amyand. Appendectomy has been the standard treatment for acute appendicitis every since Charles McBurney described it in 1889. However, studies have shown that an antibiotic first strategy may be feasible without increased risk of perforation, sepsis, and/or […]

Is Fever the New Hotness in Sepsis?

28 Mar
March 28, 2017

Background: With the introduction of sepsis 3.0, came the quick sepsis related organ failure assessment (qSOFA) score. The purpose of this score is supposed to be a bedside tool to help predict which patients are at the greatest risk of poor outcomes.  There are three components to this score: Low systolic blood pressure (≤100mmHg), high […]

Pediatric Septic Hip

06 Mar
March 6, 2017

Pediatric Septic Hip Definition: Bacterial infection of the hip joint space and synovial fluid Background: Causes Hematogenous spread in bacteremia Local spread (i.e. from osteomyelitis) Direct inoculation (traumatic or surgical) High-Risk Subgroups Age < 2 years (peak incidence 6 – 24 months) Immunocompromised state (i.e. AIDS, active cancer, etc) Functional asplenia (i.e. sickle cell disease) Complications […]

The HYPRESS Trial: Early Steroids to Prevent Septic Shock

31 Oct
October 31, 2016

Background: The most recent surviving sepsis campaign recommends the use of hydrocortisone in patients with refractory septic shock (i.e. vasopressor dependent).  However, the use of hydrocortisone in severe sepsis without shock still remains a very controversial topic. Recommendations for hydrocortisone are mostly based on 2 randomized clinical trials (i.e. Annane et al [2] and CORTICUS […]

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