Background: Aspirin is the most widely used antiplatelet agent in acute coronary syndromes. The bulk of the evidence for this came from the second international study of infarct survival (ISIS-2) published in the Lancet in 1988.
Archive for category: Cardiovascular
Background: Nitroglycerin is a first line agent in the treatment of ACS. The physiologic basis for it’s use rests on it’s ability to promote coronary vasodilation resulting in increased blood flow to the coronary arteries . Nitroglycerin, is typically given as sublingual tablets or sublingual spray of 0.3 – 0.4mg q5min x3 for ischemic chest […]
Background: The first report for supplemental oxygen for angina was in 1900, and since then oxygen therapy has been a commonly used treatment of patients with ST-Elevation Myocardial Infarction (STEMI). The reason for this is the belief that supplemental oxygen will increase oxygen delivery to ischemic myocardium and help reduce myocardial injury. This belief is […]
Background: Morphine is a commonly used medication in acute coronary syndromes (ACS) to help relieve pain which in turn can help reduce sympathetic tone. Over the past few years however, there has been some concern raised about the drug-drug interactions with antiplatelet agents causing impaired platelet inhibition as well as an association with worsened clinical […]
Background: Acute coronary syndrome (ACS) is a true spectrum of disease: STEMI, NSTEMI, Unstable Angina (UA), and Stable Angina (SA). The history and physical plus ECG help us to differentiate patients with STEMI from NSTEMI. Classically, STEMI represents complete occlusion of a culprit artery and this finding requires immediate coronary angiography and revascularization. It turns […]