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Author: Salim Rezaie

Remdesivir ACTT-1: Adaptive COVID-19 Treatment Trial Part 1

Background: The saga of Remdesivir for treatment of COVID-19 continues. We previously covered two studies of this drug on REBEL EM (Link is HERE & Link is HERE). One trial (≈200pts) showed no difference in the primary outcome of median …

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Infectious Disease

Rebellion in EM 2019: Got Milk? via Jenny Beck-Esmay, MD

“You’re working a shift in whatever the lower acuity version is of your department. So maybe it’s fast track, maybe you call it an urgent care. Whatever it is, it’s a unit where they take doctors, who trained for 7 …

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Obstetrics and Gynecology

COVID-19 Update: Just Say No to Hydroxychloroquine or Chloroquine With or Without Macrolides

This publication has now been retracted by Lancet (June 4, 2020) Background: There is no conclusive evidence that chloroquine, or its derivative hydroxychloroquine, with or without a second-generation macrolide is effective in COVID-19 treatment or prophylaxis. Laboratory studies have shown …

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Infectious Disease

COVID-19 vs H1N1: Similar but Different

Disclaimer: This post explores some of the pathophysiologic findings in severe SARS-CoV-2 infection. It explores possible mechanisms-based and posits theories BUT, this is not a clinical post. The hypothesis and findings here are not confirmed and extrapolation to management is …

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Infectious Disease

REBEL Cast Ep82: Timing of Endoscopy for UGIB

Background: Upper endoscopy allows for the identification of the source of bleeding as well as hemostatic treatment for actively bleeding lesions In patients with upper gastrointestinal bleeding (UGIB).  Definitive treatment with endoscopic hemostatic treatment can potentially stop bleeding in high-risk …

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Abdominal and Gastroinstestinal

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